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Forschung

Durch patientenorientierte klinische Studien und Grundlagenforschung können Pankreastumore erforscht und die Behandlung stetig verbessert werden.

Am Pankreaszentrum Marburg wird ausgiebig in nationalen und internationalen Forschungsverbünden zu endokrinen und exokrinen Pankreastumoren geforscht.

Viele Forschungsvorhaben werden aufgrund ihrer hohen Qualität z.B. durch die Deutsche Forschungsgemeinschaft (DFG), die EU und die Deutsche Krebshilfe gefördert.

Zudem steht unserem Forschungslabor ein transgenes Tumormausmodell zu Verfügung, das erstmalig die Entstehung des humanen Pankreaskarzinoms widerspiegelt.

Einen Überblick gibt die Auflistung der wichtigsten Publikationen aus den letzten Jahren:

Robotic-assisted approach improves vessel preservation in spleen-preserving distal pancreatectomy.
Eckhardt S, Schicker C, Maurer E, Fendrich V, Bartsch DK.
Dig Surg. 33:406-13 (2016)


C-reactive protein as a new prognostic factor for survival in patients with pancreatic neuroendocrine neoplasia.
Wiese D, Kampe K, Waldmann J, Heverhagen AE, Bartsch DK, Fendrich V.
J Clin Endocrinol Metab, 101:937-44 (2016)


ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors.
Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M,
Kos-Kudla B, Kwekkeboom D, Rindi G, Klöppel G, Reed N, Kianmanesh R, Jensen RT; Vienna Consensus Conference participants.
Neuroendocrinology 103:153-71 (2016)


Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.
Calabretta S, Bielli P, Passacantilli I, Pilozzi E, Fendrich V, Capurso G, Fave GD, Sette C.
Oncogene 35:2031-9 (2016)


Refinement of screening for familial pancreatic cancer.
Bartsch DK, Slater EP, Carrato A, Ibrahim IS, Guillen-Ponce C, Vasen HF, Matthäi E, Earl J, Jendryschek FS, Figiel J, Steinkamp M, Ramaswamy A, Vázquez-Sequeiros E, Muñoz-Beltran M, Montans J, Mocci E, Bonsing BA, Wasser M, Klöppel G, Langer P, Fendrich V, Gress TM.
Gut 65:1314-21 (2016)

Double germline mutations in APC and BRCA2 in an individual with a pancreatic tumor.
Goehringer C, Sutter C, Kloor M, Gebert J, Slater EP, Keller M, Treiber I, Ganschow P, Kadmon M, Moog U.
Fam Cancer, Epub Nov 12 (2016)


Minimally invasive versus open pancreatic surgery in patients with multiple endocrine neoplasia type 1.
Lopez CL, Albers MB, Bollmann C, Manoharan J, Waldmann J, Fendrich V, Bartsch DK.
World J Surg; 40:1729-36.(2016)


The benefit of surveillance for pancreatic cancer in high-risk individuals: outcome of long-term prospective follow-up studies from three European expert centers.
Vasen H, Ibrahim I, Ponce CG, Slater EP, Matthäi E, Carrato A, Earl J, Robbers K, van Mil AM, Potjer T, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bergman W, Wasser M, Morreau H, Klöppel G, Schicker C, Steinkamp M, Figiel J,Esposito I, Mocci E, Vazquez-Sequeiros E, Sanjuanbenito A, Muñoz-Beltran M, Montans J, Langer P, Fendrich V, Bartsch DK.
J Clin Oncol, 34:2010-9 (2016)


Laparoscopic versus open distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry.
Wellner UF, Lapshyn H, Bartsch DK, Mintziras I, Hopt UT, Wittel U, Krämling HJ, Preissinger-Heinzel H, Anthuber M, Geissler B, Köninger J, Feilhauer K, Hommann M, Peter L, Nüssler NC, Klier T, Mansmann U, Keck T; StuDoQ
Pancreas
study group and members of StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery (DGAV).
Int J Colorectal Dis, Epub Nov 4 (2016)


Familial Pancreatic Cancer: To Screen or not to Screen.
Vasen HF, Bartsch DK
EBioMedicine 2:1858-1859 (2015)

Molecular Characterization and Pathogenesis of Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Benzel J, Fendrich V.
Eur Surg Res 55: 352-363 (2015)

EndoplasmicReticulum Stress in Pancreatic Neuroendocrine Tumors is Linked to Clinicopathological Parameters and Possible Epigenetic Regulations.
Klieser E, Illig R, Státtner S, Primavesi F, Jáger T, Swierczynski S, Kiesslich T,
Kemmerling R, Bollmann C, Di Fazio P, Neureiter D.

Anticancer Res 35:6127-6136 (2015)

Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.
Lichtenauer UD, Di Dalmazi G, Slater EP, Wieland T, Kuebart A, Schmittfull
A, Schwarzmayr T, Diener S, Wiese D, Thasler WE, Reincke M, Meitinger T,
Schott M, Fassnacht M, Bartsch DK, Strom TM, Beuschlein F.
J Clin Endocrinol Metab 100:E776-782. (2015)

Long-Term Outcomes of Surgical Management of Pancreatic Neuroendocrine Tumors with Synchronous Liver Metastases.
Partelli S, Inama M, Rinke A, Begum N, Valente R, Fendrich V, Tamburrino D
Keck T, Caplin ME, Bartsch DK, Thirlwell C, Fusai G, Falconi M.
Neuroendocrinology 102:68-76 (2015)

Limited resection of pancreatic cancer in high-risk patients can result in a
secondprimary.

Potjer TP, Bartsch DK, Slater EP, Matthäi E, Bonsing BA, Vasen HF.
Gut 64:1342-1344 (2015)

LCN2 and TIMP1 as potential serum markers for the early detection of familial pancreatic cancer
Slater EP, Fendrich V, Strauch K, Rospleszcz S, Ramaswamy A, Matthäi E, Chaloupka B, Gress TM, Langer P, Bartsch DK.
Transl Oncol 2013; 6:99-103.

MicroRNAs 196a and 196b as potential biomarkers for the early detection of familial pancreatic cancer.
Slater EP, Strauch K, Rospleszcz S, Ramaswamy A, Esposito I, Klöppel G, Matthäi E, Heeger K, Fendrich V, Langer P, Bartsch DK.
Ann Surg 2013; eingereicht.

Multiple small "imaging" branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia?
Bartsch DK, Dietzel K, Bargello M, Matthaei E, Klöppel G, Esposito I, Heverhagen JT, Gress TM, Slater EP, Langer P.
Fam Cancer 2013; 12:89-96.

Variation in Precursor Lesions of Pancreatic Cancer among High-Risk Groups.
Potjer TP, Schot I, Langer P, Heverhagen JT, Wasser MN, Slater EP, Klöppel G, Morreau HM, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bargello M, Gress TM, Vasen HF, Bartsch DK; on behalf of the Leiden Familial Pancreatic Cancer Group and the FaPaCa registry.
Clin Cancer Res. 2013; 19:442-449.

Familial pancreatic cancer- current knowledge
Bartsch DK, Gress TM, Langer P.
Nat Rev Gastroenterol Hepatol 2012; 9:445-453.

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.
Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.
J Pathol 2012; 226:723-734.

Prof. Dr. med. D.K. Bartsch

Prof. Dr.med. D.K. Bartsch

Prof. Dr. med. T. Gress

 
 
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